Multiple arrests were made after anti-Immigration and Customs Enforcement protesters occupied a Manhattan hotel lobby Tuesday night, cops said.

The protesters entered the lobby of the Hilton Garden Inn Tribeca on Sixth Ave. near West Broadway around 6 p.m., police said.

Police began making arrests after protesters refused multiple orders to disperse, according to law enforcement.

Video posted to social media shows dozens of protesters inside the hotel lobby holding signs that read “Hilton stop housing ICE,” and “Hilton don’t let ICE stay,” as hundreds more chanted “NYPD go to hell, it is right to rebel” outside the building.

A law enforcement source told the Daily News approximately 300 protestors were outside the building, with another 100 gathered inside the lobby.

The 6th Ave. Hilton locked its doors in the wake of Tuesday’s protest, with only guests and staff allowed in or out.

“This has got to stop,” said a Hilton executive, who spoke to a Daily News reporter at the scene and refused to provide his name. “We can’t have a hundred people surrounding and going into a hotel. There’s going to be a lot of pain going forward. This is an innocent hotel.”

When pressed regarding whether the hotel was hosting federal Immigration and Customs Enforcement agents, the executive said, “I can’t tell you that.”

A man staying with his wife and 4-year-old daughter at the hotel called the protestors “scumbags.”

An NYPD spokesman could not immediately say how many protesters were arrested, or what they were charged with.

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